Molecular controls of mitosis/meiosis decision in C. elegans by conserved RNA regulators, FBF and GLD-2
To investigate the molecular switch controlling the mitosis/meiosis decision, I first set out to identify target mRNAs of the GLD-2 cPAP using a candidate gene approach. I found that GLD-2 directly activates gld-1 mRNA and this activation identifies a positive regulatory step to drive germ cells robustly into meiotic cell cycle. Interestingly, that same RNA was previously shown to be a direct target of FBF repression.Switch from mitosis to meiosis Above, diagram of the distal gonad. The somatic distal tip cell (red) resides at the distal end of the gonad and signals to germ cells to remain in mitosis; other cells in the diagram are germ cells. The aquot;mitotic regionaquot; anbsp;...
| Title | : | Molecular controls of mitosis/meiosis decision in C. elegans by conserved RNA regulators, FBF and GLD-2 |
| Author | : | Nayoung Suh, The University of Wisconsin - Madison |
| Publisher | : | ProQuest - 2007 |
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