Rabies transmission
Infection occurs primarily through bites or wounds caused by infected saliva entering a cut, open wound or mucosa.The virus remains generally a period of time in the place of entering the body before reaching the brain through nerves. In the brain, the virus multiplies rapidly, causing the appearance of clinical manifestations. The virus then moves from the brain through nerves, to the salivary glands. The period of time before clinical signs in an infected animal may vary, depending on the virus strain and the point of entering the body.
The virus is transmitted by direct contact of the saliva of an infected animal with the blood of another animal- so, if an healthy animal is bitten by an infected animal, the rabies transmission is made easily. Rabies transmission is made through bites or scratches of the infected animals. The most serious are those located in the neck and head area, because the virus reaches the brain faster.
An animal infected with rabies virus may begin to shed it, up to fifteen days before the first signs. The virus is present in all the secretions of the animal, including its feces. Given its fragility in the external environment, the entry of the virus into the body occurs only through a break in the skin or by oral or ocular mucosa. There were outlined a number of cases of rabies transmission from human to human through cornea transplant.
Rabies transmission "in vitro" can also happen through aerosol path, through mucous membranes; this is, for example what happens in the caves inhabited by bats: there were reported two cases of speleologists who contracted rabies after being in contact with aerosols from the bat. In aerosol transmission, the virus enters the body through the nasal epithelium and is subsequently transported to the olfactory bulb. More uncommon, transmission may also occur in a surgery of corneal transmission. It is thought that the virus replicates in the neurons of the olfactory bulb before spreading to other neurons in the brain. Neuronal virus transmission from the periphery of the body to the brain is called "centripetal virus spread."
In Europe, terrestrial non-flying vectors of rabies can be the fox, the wolf, the badger, the deer, but also the dog, the cat and the cow. In America, rabies is transmitted by raccoons or coyote.
Rabies transmission is made often by biting but can also be transmitted by simply licking. After human infection, the virus enters (directly or indirectly) the peripheral nervous system. It then travels along nerves to the central nervous system. During this phase, it can not be easily detected by the immune system of the host, and vaccination may still confer immunity. Once the virus reaches the brain, it rapidly causes encephalitis and symptoms appear. It can also infect the spinal cord, causing myelitis.